WWOX and neoplasm: Several lines of evidence have associated WWOX with tumor suppression activity through its regulation of key cancer-signaling pathways, such as WNT, TGFβ1, NF-kappaB, and RTK [17,18,19,20,21,22,23,24,25], cellular metabolic pathways (HIF1α and IDH) [26,27], and response to DNA damage (ATM, p63 and p73) [28,29,30], all of which known to be directly involved in tumorigenesis.