Germline, bi-allelic, and pathogenic variants of WWOX have been described in the neurodevelopmental disorders WWOX-related epileptic encephalopathy (WOREE, DEE28) syndrome and spinocerebellar ataxia type 12 (SCAR12), however, despite knowing the genetic cause, the precise role of WWOX and the genotype–phenotype correlations of these disorders remain elusive. The gene discussed is WWOX; the disease is neurodevelopmental disorder.