Germline, bi-allelic, and pathogenic variants of WWOX have been described in the neurodevelopmental disorders WWOX-related epileptic encephalopathy (WOREE, DEE28) syndrome and spinocerebellar ataxia type 12 (SCAR12), however, despite knowing the genetic cause, the precise role of WWOX and the genotype–phenotype correlations of these disorders remain elusive. This evidence concerns the gene WWOX and developmental and epileptic encephalopathy, 28.