WWOX and Severe short stature: Suzuki et al. reported that a spontaneous deletion of 13-bp in exon 9 within the WWOX gene of the lde/lde (lethal dwarfism with epilepsy) rat was associated with dwarfism, ataxic gait, high incidence of epileptic seizures, and postnatal lethality [36] providing direct evidence for the role of WWOX in CNS biology.