The median maternal GCF-PLAP concentration was 63.7 (interquartile range (IQR): 88.9) pg/mL in healthy patients (12,3%), 46.6 (IQR: 47.2) pg/mL in patients with gingivitis (28.5%), and 42.4 (IQR: 46.7), 41.1 (IQR: 51.8), 34.7 (IQR: 46.88) pg/mL at periodontitis stage I (33.1%), stage II–III (16.1%) and stage IV (10%), respectively, without statistically significant differences among them (p-value = 0.407). This evidence concerns the gene ALPP and periodontitis.