Predominance of CD4+ T-lymphocytes and IFN-γ was shown in herpes associated erythema multiforme (HAEM), while in a drug-induced erythema multiforme (DIEM) there is involvement of monocytes, CD8+ T-lymphocytes and tumor necrosis factor-α (TNFα) [9]. The gene discussed is TNF; the disease is erythema multiforme.