In humans, several mutations in the gene coding for asparagine synthetase (ASNS) have been identified as being associated with asparagine synthetase deficiency (ASD), resulting in neurological problems and microcephaly [31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47]. The gene discussed is ASNS; the disease is Congenital microcephaly-severe encephalopathy-progressive cerebral atrophy syndrome.