As A6E mutation does show a common effect on the protein expression of asparagine synthetase in both yeast and humans, this suggests that yeast could be an alternative model of ASD, as already seen in several studies using yeast as models of amyloid and neurodegenerative diseases [49,50,51,52,53,54,55,56,57,58]. Here, ASNS is linked to neurodegenerative disease.