Second, due to the retrospective nature of the study, we have no data on the microsatellite instability/mismatch repair status and somatic alterations (i.e., KRAS, NRAS, and BRAF mutations) of tumors, which are important markers to discriminate colorectal cancer patients with a different response to therapy and prognosis [14,15,16]. This evidence concerns the gene NRAS and colorectal cancer.