Remarkably, in the WD-fed Cisd2TG mice after 4 months, the two-fold overexpression of Cisd2 could be seen to have obviously brought about a decrease in lipid droplet deposition, while at the same time there had been a discernible attenuation of liver inflammation and reduced liver fibrosis (Figure 2A). Here, CISD2 is linked to Hepatic fibrosis.