IL6 and Hepatic fibrosis: An overview of the interconnection between fatty acid metabolism and the cholesterol synthesis pathway is presented in Figure 4D. Moreover, in the WD-fed Cisd2hKO+/− mice, despite the fact that the “hepatic fibrosis” pathway and the “IL-6-mediated” pathway are not selected as within the top list annotated by IPA, a certain number of genes involved in these two pathways are also significantly induced in the WD-fed Cisd2hKO+/− mouse livers compared with those of the WT mice.