PRSS57 and infection: The latter could be related to the fact that in the event of an infection with rotavirus endotoxin non-structural protein 4 (NSP4) is produced intracellularly and the upregulation of Ca2+ has an influence on the Ca2+-sensitive proteins F-actin, villin, and tubulin, resulting in damage of the microvillar cytoskeleton of the cell [77,81,82].