Wogonin, a flavonoid-like compound found in Scutellaria baicalensis (known as Baikal skullcap or Chinese skullcap), has been discovered that triggered apoptosis of U-2OS human osteosarcoma cells by augmenting the expression of both intrinsic and extrinsic apoptosis components, including Bax, Bad, cytochrome C, cleaved caspase-9, cleaved caspase-3, AIF, Endo G, Fas, caspase-8, and caspase-4 [89]. This evidence concerns the gene CASP3 and osteosarcoma.