AGER and Alzheimer disease: The role of the BBB breakdown and dysfunction and the dysregulation of certain BBB transporters such as the ABCB1, the lipoprotein receptor-related protein (LRP-1), and the receptor for advanced glycation end products (RAGE) have been studied extensively in vitro, in vivo, and using post-mortem brain analysis of AD patients as key factors in the development and/or the progression of the disease [112,113,114].