BDNF and obesity due to melanocortin 4 receptor deficiency: However, there were insignificant differences in overweight/obesity (p > 0.05, Cohen’s d = 0.22), EC (p > 0.05, Cohen’s d = −0.10), BDNF (p > 0.05, Cohen’s d = −0.20), and 5-HT (p > 0.05, Cohen’s d = 0.15) between the two genders (Table 1).