In BC adiponectin exerts its function through activation of numerous signaling pathways, e.g., (i) decreases the phosphorylation of PI3K and Akt, (ii) induces AMPK activation suppressing mTOR pathway, (iii) induces cell cycle arrest through the downregulation of cyclin D, thus preventing breast tumor growth [124], and (iv) negatively impact lamellipodia formation, thus preventing cell migration and invasion [118]. The gene discussed is AKT1; the disease is breast cancer.