Importantly, the mentioned anti-proliferative and pro-apoptotic effects of adiponectin were seen in mostly ERα-negative BC, while divergent effects of adiponectin were reported in ERα-positive BC such as: (i) activation of both MAPK and Akt stimulating mTOR/p70S6K cascade, (ii) activation of ERα followed by recruitment of LKB1 as a receptor coactivator overall compromising AMPK and in consequence switching cancer cell energy balance vs. lipogenic aggressive phenotype, and (iii) upregulation of cyclin D1 promoting tumor growth [125]. The gene discussed is ESR1; the disease is breast cancer.