TNF and neoplasm: The enlarged adipocytes release more of FFAs and together with infiltrating immune cells are the primary sources of many inflammatory proteins, including CCL2, TNF-α, IL-6, IL-18, leptin, resistin, plasminogen activator inhibitor (PAI)-1, visfatin, retinol binding protein 4 (RBP4), and angiopoietin-like protein 2 (ANGPTL2), contributing to tumor progression.