Recent studies have evidenced that high levels of leptin produced by obesity-altered ASCs derived from human lipoaspirate of SAT isolated from obese women promote TNBC cell migration and metastasis as well through induction of EMT process [146] as well as growth and metastasis in ERα-positive BC [147]. The gene discussed is ESR1; the disease is obesity due to melanocortin 4 receptor deficiency.