CRP and rheumatoid arthritis: The CRP level (mg/l) in disease-affected subjects was significantly higher in the ApaI aa genotype vs. Aa (p = 0.0049), in the FokI Ff genotype vs. ff (p = 0.0162), and in the aa vs. ff (p = 0.0061), suggesting that the ApaI aa variant is associated with a higher CRP concentration in RA subjects (Figure 2).