Distinction between gingivitis and periodontitis groups has been analyzed by only one study, which reported sensitivity of 81% and specificity of 71% for the combination of IL-6 and MIP-1α; meanwhile, a combination of IL-1β, IL-6, MMP-8, and MIP-1α was found to have a good sensitivity of 78% and specificity of 78% [84]. This evidence concerns the gene MMP8 and periodontitis.