Activated M1 macrophages can be distinguished by general expression of surface proteins HLA-DR and CD80/86, but numerous others have also been described (CD64, CD16, CD120b, TLR2, and SLAMF7 etc.)The activated M2 macrophages on the other hand are considered to be predominantly tumor associated, as they are characterized by the ability to produce anti-inflammatory cytokines (e.g., IL-10, TGFβ, etc.)and pro-angiogenic factors (e.g., VEGF, TNFα, etc.). The gene discussed is CD80; the disease is neoplasm.