It is commonly built of neoplastic cells, supportive tissue (extracellular matrix) and cells (fibroblasts), and an immune infiltrate consisting of a grand variety of immune cells, such as neutrophils, natural killer (NK) cells, tumor associated macrophages (TAMs) myeloid derived stem cells (MDSC), dendritic cells, and several subsets of lymphocytes such as CD4+ T helper cells, CD8+ cytotoxic T cells, and regulatory CD4+Fox(forkhead box)P3+ Tcells (Treg). The gene discussed is CD8A; the disease is neoplasm.