In this matter, intratumoral CD8+ T cells were seemingly inversely associated with PD-L1 expression in OSCC from one retrospective study [109], while Sanchez-Cantelli et al. [110] noticed an increased infiltration of CD8+ TILs in HPV− SCCHN with high PD-L1 expression. Here, CD274 is linked to head and neck squamous cell carcinoma.