VEGFA and glioblastoma: In previous work, we demonstrated that PKC activation induced a two-fold increase in PR transcriptional activity when GBM cells (U251) were transfected with the MMTV-Luc reporter plasmid carrying two PRE [24]; thus, LPA treatment induces PKCα activation (through LPA1 receptor), that in turns phosphorylates PR, modulating VEGF expression by PRE.