Interestingly, they evidenced an increased production of pro-inflammatory cytokines (IFN-γ, IL-1β, IL-6, TNF-α) in the supernatant of both direct and indirect co-cultures when HT29 cells were co-cultured with either peripheral or infiltrated tumor CD8+ T-cells in presence of DAPT. The gene discussed is CD8A; the disease is neoplasm.