Note that once the plasma cells triggered by this non-classical mechanism become exhausted, the corresponding memory B cells will hardly become activated because they lack the support of T helper cells (which are eliminated by the self-tolerance mechanisms) and will outcompete the natural autoantibodies (which are of IgM type and therefore of lower affinity)—potentially explaining why the autoimmune response is not further increased or even decreased in morbid obesity. This evidence concerns the gene CD40LG and morbid obesity.