For instance, in DSS-treated female institute of cancer research (ICR) mice, supplementation of a standard rodent diet with 0.5% soy isoflavones significantly enhanced occludin colonic mRNA [149], whereas in DSS-treated female BALB/C mice, genistein supplementation (600 mg/kg diet) enhanced both ZO-1 and occludin colonic mRNA, as well as lowered serum LPS (as a marker of colonic permeability) following colitis induction [167]. This evidence concerns the gene OCLN and cancer.