Of interest, COX-2 was not inhibited in DSS-treated C57BL/6 mice fed pure soy BBI (despite the anti-inflammatory effect of pure soy BBI in the DSS model), whereas in the same model, the attenuation of DSS colitis in mice fed pea seed extract containing BBIs was accompanied by significant reductions in COX-2 mRNA expression [212]. This evidence concerns the gene PTGS2 and colitis.