Other studies have reported that the reduction in PKCδ affects glioma invasiveness through its relationship with the regulation of the extracellular matrix components; indeed, the interference of PKCδ expression reduced the release or extracellular levels of the protein tenascin-C, resulting in the downregulation of matrix metalloprotease MMP-12, a metalloprotease required for cell migration and involved in tumor invasion [130]. This evidence concerns the gene PRKCD and central nervous system cancer.