2HG formation by wild-type IDH2 in breast cancer was also reported by Terunuma [11] and associated with the activity of the Myc oncogene, which augments glutaminolysis, and thus supports also reductive reactions catalyzed by IDH2, i.e., the reductive carboxylation (RC) into isocitrate (IC) and reduction of 2OG into 2HG. The gene discussed is IDH2; the disease is breast cancer.