KLK3 and breast cancer: Men with a personal history of Gleason ≥7 PCa with a family history of a BRCA1/2 mutation, or one close relative with ovarian or breast cancer at age <50 years, or two relatives with breast, pancreas, or Gleason ≥ 7 PCa at any age, should undergo genetic counseling [6].Currently, the IMPACT multicenter observational study is evaluating the utility of performing these screenings, it being understood that men with age 40–69 are offered annual PSA and the threshold for prostatic biopsy is PSA > 3 ng/mL [30].