Labial minor salivary gland biopsy specimens from individuals with SD demonstrated an IFN signature in 58% of individuals, with further analyses identifying three IFN-related patterns nearly evenly distributed: patients with type I IFN dominant signature, those with type II IFN dominant signature, and those with a combined type I and type II IFN signature [12,13,14]. This evidence concerns the gene IFNA1 and Salla disease.