IRF5 and systemic lupus erythematosus: As B-cells have a dual function being involved in both antigen presentation, in association with dendritic cells, and autoantibody production, several SLE-associated genes affecting B-cell receptor (BCR) function and intracellular signaling (such as BANK1, RasGRP3, the Src-family associated tyrosine kinases-LYN/BLK/CSK-, TLR7-9, IRF5, IRF7) have been linked to the disease pathogenesis [1].