The crosstalk between ECs and cancer cells potentiates tumor angiogenesis mediated by β-AR signaling pathway, inducing the EC activation of Jagged1/Notch intercellular signaling and the metabolic shift of ECs from oxidative phosphorylation to aerobic glycolysis, which represents a critical step during the angiogenic switch [203,206]. This evidence concerns the gene ADRB2 and neoplasm.