APC and colorectal cancer: Other mouse models with target genetic modifications at different locations on the APC gene have been generated, such as ApcMin/850, ApcΔ716, Apc1638N, Apc1638T, ApcΔ468, and ApcΔ474 [10], that allow the study of the colorectal cancer mechanisms, create models more similar to those changes found in humans, and test the role of specific regions in the APC gene on cancer development [9,10].