A study done by Muniyappa and colleagues using two-dimensional difference gel-electrophoresis (2D DIGE) protein profiling demonstrated that miR-29 is downregulated in highly invasive and poorly differentiated lung carcinoma cells [22] and targets several metabolic enzymes involved in various pathways including enolase-alpha (ENO1), phosphoglycerate kinase 1 (PGK1), phosphoglycerate mutase (PGAM1), cytidine monophosphate kinase (CMPK1) and lysophospholipase II (LYPLA2). This evidence concerns the gene ENO1 and lung carcinoma.