Similar to the mRNA levels shown in Figure 1, CRBN protein expressions in clear cell renal cell carcinoma (RCC), lung adenocarcinoma, uterine corpus endometrial carcinoma (UCEC), and colon cancer were markedly downregulated compared to their normal tissue counterparts, which corresponded with their mRNA expression differences (Figure 4a,d). Here, CRBN is linked to colonic neoplasm.