TGFB1 and cancer: Based on the KIRC subtype, the ccA subtype overexpresses a set of genes involved in hypoxia, angiogenesis, fatty acid metabolism, and organic acid metabolism, whereas the ccB subtype overexpresses genes involved in cell differentiation, epithelial to mesenchymal transition (EMT), cell cycle, and transforming growth factor beta (TGFβ), resulting in a more aggressive cancer progression [38].