In the course of the disease, MM-cells acquire additional genetic lesions, such as deletion 17p with subsequent mono-allelic loss of p53, 1q gain with the amplification of 679 genes (i.e., BCL9, PDZK1), and copy-number variations or translocations affecting MYC, as well as somatic mutations of multiple signaling molecules [24,25,26,27]. Here, TP53 is linked to Miyoshi myopathy.