SRC and cancer: Although the SRC variant was reported in only 6 of 125,748 exomes of the gnomAD database, it was found in 4 additional index cases among 1690 tested Polish CRC families and in 3 out of 1676 controls, implying that it may be a moderate risk allele, explaining the non-complete penetrance of cancer in the family and also the diverse pattern of cancers which may be due to additional mutation(s).