Confirming the functional impact of the studied SRCV177M variant on key components of the described cancer related pathways (PXN, Wnt, STAT3, MAPK/ERK signaling, Figure 5b), we aim to confirm the postulated involvement of upregulated SRC activity in colorectal carcinogenesis and further to implicate these molecular mechanisms in cancer development of the studied family. This evidence concerns the gene STAT3 and medical procedure.