KDM6A and Kabuki syndrome: This might be the case of subunits of the KMT2D complex; in fact, KMT2D and lysine demethylase 6A/ubiquitously transcribed tetratricopeptide repeat protein X-linked (KDM6A/UTX) mutations have been observed in patients that are affected by Kabuki Syndrome [229,230,231,232,233,234,235,236,237] and, in line with that, kmt2d knockout in zebrafish recapitulates the Kabuki phenotype and it is characterized by the deregulation of the Notch pathway [238].