SHARP mutations have been also described in diffuse large B-cell lymphoma (DLBCL) [135], in splenic marginal zone lymphoma (SMZL) [136,137], in pancreatic adenosquamous carcinoma (PASC) [138], as well as in neurodevelopmental disorders (NDDs) [139]. The gene discussed is SPEN; the disease is diffuse large B-cell lymphoma.