Periodontal disease is associated with higher levels of acute phase proteins, plasma antibody levels, coagulation factor, total white blood cell count, neutrophils, C reactive protein (CRP), and cytokines such as IFN-γ (interferon-gamma), TNF-α (Tumor Necrosis Factor-Alpha), IL (Interleukin)-1β, IL-2 and IL-6. This evidence concerns the gene TNF and periodontal disorder.