Clear-cell ovarian carcinoma (CCOC) represents a distinct entity of OC, associated with a unique clinical and genetic pattern [102] When diagnosed in the early stage, CCOC is generally associated with a better prognosis than HGSC; however, in the advanced setting, the prognosis of CCOC is dismal, with poor response to standard treatments [102] The genomic landscape of CCOC is characterized by recurrent pathogenic dysregulation of the PIK3CA-AKT-PTEN-mTOR pathway in nearly half of all cases. This evidence concerns the gene PIK3CA and ovarian clear cell cancer.