Of note, despite its low circulating concentration in plasma, acetate could still exert its effects through intra- and intercellular recycling of acetate molecules within the tumor microenvironment, leading to the role of acetate as a positron emission tomography (PET) imaging probe for cancer as well as an exploitable metabolite for future anti-ACSS2 therapy against cancer [83]. This evidence concerns the gene ACSS2 and cancer.