Of interest, BRD4 inhibition induced homologous recombination deficiency (HRD) and sensitized cells across multiple tumor lineages to PARP inhibitors, regardless of BRCA1/2, TP53, RAS, or BRAF mutation status, through depletion of the DNA double-stand break resection protein CtIP (C-terminal binding protein interacting protein) [115]. The gene discussed is TP53; the disease is neoplasm.