Correspondingly, our recent study demonstrates that mTORC2 promotes histone acetylation (H3K9ac, H3K18ac, H3K27ac) in the actively transcribed promoters of GBM cells through metabolic reprogramming/Warburg effect (hence the production of nuclear acetyl-CoA) and dysregulation of histone modifying enzymes including PDH and HDACs [77]. Here, PDP1 is linked to glioblastoma.