Mutations in cAMP-responsive element-binding protein (CREB)-binding protein (CREBBP) and EP300, that are the responsible genes for Rubinstein–Taybi syndrome of multiple congenital anomalies, could also be involved in hematological cancer including those leukemias where chromosome translocations disrupt the CREB-binding protein (CBP) gene function [24]. This evidence concerns the gene CREBBP and hematopoietic and lymphoid cell neoplasm.