PDP1 and glioblastoma: Of interest, acetyl-CoA can be produced by PDH from glucose and by acyl-coenzyme A synthetase short-chain family member 2 (ACSS2) from acetate, both of which are closely associated with the biology of the malignant brain tumor, glioblastoma (GBM), through acetylation of cytosolic proteins (Figure 2) [81].