Future studies in this type of tumour could confirm or contribute to several aspects of CAFs, such as CAF heterogeneity and plasticity, factors that participate in the conversion of CD34+SCs/TCs into CAFs, and CAF functions, including extracellular matrix deposition and remodelling, CAF-related factors that participate in tumour growth, invasion, metastasis and angiogenesis, as well as those that modulate tumour immunity (for review, see [29,51]). This evidence concerns the gene CD34 and neoplasm.