The aberrant T cell immunophenotypes identified in EAE patients are: CD3-CD4- clonal T cells (which are also common in the lymphocytic variant of HES) [9,24,25], CD3-CD4+, CD3+CD4+CD7-, CD3-CD3ic+CD4-CD8-CD7+CD5+, CD3+CD4-CD8-CD2+CD5+CD7+TCRγδ+ phenotype [12], and CD3+CD4-CD8- lymphocyte population [15]. The gene discussed is CD7; the disease is hypereosinophilic syndrome.