In addition, because one of the most common presentation in EAE is the swelling affecting the face (80%) [12], this condition should be differentiated from hereditary (HAE) and acquired bradykinin-mediated AE (AAE) (for patients presenting with AE without urticaria), and from histamine-mediated AE (for patients experiencing concomitant pruritus and urticaria). The gene discussed is KNG1; the disease is hereditary angioedema.