KIT and mitochondrial neurogastrointestinal encephalomyopathy: Examination of the small intestine neuromuscular pathology in patients with MNGIE has shown an absence of c-Kit-positive interstitial cells of Cajal around the myenteric plexus, intermuscular septa and within muscular plexus, which may be associated with cell death or trans-differentiation into a smooth muscle phenotype [66,67].