RRM2 and lung cancer: CDK1, which is one of the hub genes identified in their study, is a known interactor of three MPM-associated genes, namely, LYN, SP1 and RRM2, and we showed that it has association to MPM in three omics datasets: high expression correlated with unfavorable lung cancer prognosis, differential expression in MPM tumors versus adjacent pleural tissue, and isolation as an exosome-derived protein in malignant mesothelioma cell lines.