RIGI and congenital heart disease: For example, they highlighted the role of cilia and mitochondria in congenital heart disease [18,19], that oligoadenylate synthetase-like protein (OASL) activates host response during viral infections through RIG-I signaling via its PPI with retinoic acid-inducible gene I (RIG-I) [17], and led to the identification of drugs potentially repurposable for schizophrenia [20], one of which is currently under clinical trials.