Currently, mesothelioma biologists only study a handful of genes, such as BAP1, CDKN2A and NF2. To shed light onto the other MPM-associated genes, whose functions remain poorly characterized, we assembled the ‘MPM interactome’ with ~2400 previously known PPIs and 364 computationally predicted PPIs (five of which have been validated in this work), which along with their biological annotations are being made available to researchers. Here, NF2 is linked to mesothelioma.