Moreover, increasing SE was observed in every stage of cancer for the combination of markers: MMP-7 + CA 15-3 (stage I: 35.0%; stage II: 45.0%; stages III + IV: 90.0%); MMP-26 + CA 15-3 (stage I: 27.5%; stage II: 50.0%; stages III + IV: 87.5%); MMP-7 + MMP-26 + CA 15-3 (stage I: 40.0%; stage II: 57.5%; stages III + IV: 92.5%). This evidence concerns the gene MMP26 and cancer.