Finally, the considerable similarities of the long isoform of seipin in primates, but especially in the great apes, the differences in the expression of BSCL2 between humans and rodents in the brain, and the reduction of its expression in the human brain during aging [3] raise attractive hypotheses regarding the role of seipin in the encephalization process and in the etiopathogenesis of other, more common, neurodegenerative diseases. Here, BSCL2 is linked to neurodegenerative disease.