These neurological disorders are clinically heterogeneous, including Silver syndrome or spastic paraplegia 17 (SPG17; MIM: # 270685), variants of Charcot–Marie–Tooth disease type 2, and distal hereditary motor neuropathy type 5C (dHMN5C, MIM: # 619112) [68]. The gene discussed is BSCL2; the disease is Autosomal dominant spastic paraplegia type 17.