LRRK2 and Parkinson disease: Successful generation of iPSC-derived DaNs from patients harboring PD mutations or alterations in GBA (RecNcil, L444P, N370S) [48,49], SNCA (triplication) [50,51,52], or LRRK2 (G2019S) [53,54,55,56] has elucidated the role of α-syn in the origin and progression of PD.