Using ingenuity pathway analysis (IPA), they found that the downregulation of HDAC4-controlled genes occurs early along the axis of disease and that pharmacological modulation of HDAC4 activity or localization rescued PD-related phenotypes, including ER stress and autophagic and lysosomal perturbations, and increased in α-syn release. The gene discussed is HDAC4; the disease is Parkinson disease.