APOE and atherosclerosis: In the same way, an in vivo study in a model of 24 apoE-deficient mice fed with a high-fat diet was divided into two groups: carboxymethyl cellulose sodium by gavage (CMCNa) group (n = 12, 0.5% CMCNa) and the quercetin group (12.5 mg/kg/d in 0.5% CMCNa by gavage) to investigate whether quercetin improves RCT in an atherosclerosis model of “apoE-/- mice” and the underlying mechanism by molecular techniques.