However, the relationship between Tregs and tumor progression in CRC is less clear; some studies suggested that high infiltration of FoxP3+ Tregs is associated with a favorable prognosis in CRC [7,8], while others reported the association of Tregs with a poor prognosis and attributed it to Treg heterogeneity [9,10]. The gene discussed is FOXP3; the disease is colorectal carcinoma.