This is consistent with previous findings showing that the DNMT3B gene was downregulated in CD4+ TILs from CRC patients with advanced stages [15], indicating that transcriptional silencing through DNA methylation in CD4+ TILs could be associated with poor prognosis; KAT2B is important to skew Th1 differentiation into Tregs [42]; HDACs, including HDAC5, could prevent the induction and differentiation of Th1 cells [43,44], and reduced levels of KDM5B and KDM6B can positively skew Th2 differentiation [45,46]. This evidence concerns the gene CD4 and colorectal carcinoma.