SEC62 and cancer: Based on the finding that the stimulation of cancer cell migration by Sec62 is probably mediated through its influence on the calcium efflux from the ER lumen, the calmodulin inhibitor trifluoperazine (TFP) was identified as a potent agent to antagonize the calcium effect of Sec62 on cellular calcium level, and thereby counteracts Sec62 mediated cancer cell migration and metastasis [8].