Singh and colleagues used KEAP1-mutated non-small-cell lung cancer (NSCLC) cell lines stably carrying ARE luciferase reporter gene fragment as screening platforms and identified ML385 as a potent NRF2 inhibitor that directly binds to NRF2 then interrupts the binding of NRF2–MAFG complex to ARE. The gene discussed is KEAP1; the disease is non-small cell lung carcinoma.