HDAC6 and central nervous system cancer: Therefore, although we found that HDAC6 inhibitors affected ciliary aaTub similarly in murine glia and human/murine glioma, Western blot analyses of ARL13B, a protein required for both ciliogenesis and cilia signaling, suggested there may be both inhibitor- and cell-type-specific differences in the ciliary response to HDAC6 inhibition.