Overall, TCs have been found to carry a higher number of mutations than TMs with recurrent mutations of known cancer-related genes, including TP53, CYLD, cyclin-dependent kinase inhibitor 2A (CDKN2A), BRCA1 associated protein 1 (BAP1), and polybromo 1 (PBRM1) [19]. The gene discussed is PBRM1; the disease is cancer.