Lou et al. (2016) found an attenuation of focal cerebral ischemia-reperfusion injury in rats by treatment with β-caryophyllene through enhanced expression of Nrf2 and HO-1, and restored activity and expression of antioxidant enzymes, i.e., superoxide dismutase (SOD) and catalase (CAT) [157]. Here, CAT is linked to Cerebral ischemia.