We also observed that RAGE inhibition affected the classical NF-κB signaling pathway by decreasing the phosphorylation levels of p65, further supporting the hypothesis that the RAGE signaling pathway contributes to tumor survival in the presence of gemcitabine, and that RAGE inhibition could enhance the effect of gemcitabine in tumors (Figure 6). The gene discussed is NFKB1; the disease is neoplasm.