We analyzed the levels of caspase 3 and cleaved caspase 3 in the different tumor extracts by Western blot analysis, and observed significantly higher levels (p = 0.004) of cleaved caspase 3 and caspase 3 in the tumors treated with IgG 2A11 and gemcitabine than in the tumors treated with control IgGs and gemcitabine (Figure 4A). This evidence concerns the gene CASP3 and neoplasm.