miR-100 additionally inhibits IGF-1R expression not only in hepatocellular carcinoma cells [30] but also in retinal ganglion cells [33], highlighting the significance of miR-100 in regulating the IGF-1R/Akt-mediated pro-survival signals and implicating its clinical applicability in preventing retinal ganglion cell death. This evidence concerns the gene AKT1 and hepatocellular carcinoma.