Moreover, an animal study by using streptozotocin-induced diabetic retinopathy corroborates that upregulation of NF-κB- and VEGF-responsive miRNAs in the retina and retinal endothelial cells constitute a key miRNA signature that contributes to pathologic changes of early diabetic retinopathy [54], implicating a negative feedback regulation of NF-κB activation during ocular neovascularization. Here, NFKB1 is linked to diabetic retinopathy.