CNR1 and Alzheimer disease: The majority of these immunoregulatory effects are attributable to the activation of CB2R, expressed both on microglia and brain-infiltrating immune cells, although there is also evidence for the involvement of CB1R in mitigating the immune response, as in the case of traumatic brain injury, Multiple Sclerosis (MS) and Alzheimer’s disease (AD) models [52,141,142,143].